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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Isolation of autism susceptibility genes

Principal Investigator

Principal Investigator

Stefansson, Kari

Description

Description

Although genome-wide linkage scans and association studies have provided some promising leads in identifying genes that contribute to autism, no clear links have been established. This study builds on genomic data gathered in cohorts of extended families in both Iceland and the U.S. in which one or more family members have an autism diagnosis. The genome-wide linkage scans in these cohorts have revealed a number of suggestive gene loci for autism or autism-related endophenotypes, including quantitative trait loci (QTLs). Although not necessarily genes themselves, QTLs are stretches of DNA that are closely linked to the genes that underlie a specific trait. This study will phenotype additional relatives in Iceland and the U.S. and analyze both cohorts in parallel, performing the same QTL analysis, followed by fine mapping and narrowing regions of shared linkage. The focus will be on the isolation of genes within loci that are supported in both populations.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

591231

Current Award Period

Current Award Period

2006-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Project Link

Project Link

Isolation of autism susceptibility genes (External web link)

Institution

Institution

deCODE Genetics, ehf.

State/Country

State/Country

Iceland

Project Number

Project Number

5R01MH071425-05

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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