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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Molecular analysis of bipolar and schizophrenia candidate genes

Principal Investigator

Principal Investigator

Lachman, Herbert

Description

Description

This proposal describes experiments that will help identify regions of the genome involved in regulating the expression of candidate genes for schizophrenia, bipolar disorder, autism spectrum disorders and other neuropsychiatric disorders. Understanding how these genes are regulated may lead to novel treatment strategies. The ChIP-Seq screening tool will be used. This has the potential to identify regulatory elements in all previously characterized candidate genes, as well as those identified in the future, providing researchers with biologically active sites that can be efficiently screened to identify patient-specific mutations. Furthermore, it will help identify whether mutations in these regulatory regions are responsible for disease susceptibility in a subgroup of patients.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

408400

Current Award Period

Current Award Period

2011-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Project Link

Project Link

Molecular analysis of bipolar and schizophrenia candidate genes (External web link)

Institution

Institution

Albert Einstein College of Medicine of Yeshiva University

State/Country

State/Country

New York

Project Number

Project Number

2R01MH073164-04A1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Molecular analysis of bipolar and schizophrenia candidate genes | 415000 | 2012 | 5R01MH073164-05

 
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