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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Center: The pharmacogenetics of treatment for insistence sameness in autism

Principal Investigator

Principal Investigator

Owley, Thomas

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE). Insistence on Sameness (IS) is a common feature of ASD, and IS has been hypothesized to be due to improper serotonin regulation in this population. Many patients with ASD and IS benefit from treatment with medications that affect serotonin, in particular the selective serotonin reuptake inhibitors (SSRIs); however, there is little information available about which particular IS symptoms respond to SSRIs or which patients might be better candidates based on the presenting symptoms or their genetic variation. Clinical response to selective serotonin reuptake inhibitors (escitalopram) and effect of genetic variation in the serotonin transporter/receptor genes (SLC6A4 and HTR2A) on Insistence on Sameness (IS) symptoms will be explored in this pharmacogenetic study.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

378379

Current Award Period

Current Award Period

2007-2012

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LA. Complete at least three randomized controlled trials on medications targeting core symptoms in people with ASD of all ages by 2014. IACC Recommended Budget: $22,200,000 over 5 years.

Project Link

Project Link

ACE Center: The pharmacogenetics of treatment for insistence sameness in autism (External web link)

Institution

Institution

University of Illinois at Chicago

State/Country

State/Country

Illinois

Project Number

Project Number

5P50HD055751-05

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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