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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Altered placental tryptophan metabolism: A crucial molecular pathway for the fetal programming of neurodevelopmental disorders

Principal Investigator

Principal Investigator

Bonnin, Alexandre

Description

Description

The PI hypothesizes that maternal inflammation alters TRP metabolism in the placenta by perturbing the 5-hydroxytryptophan (5- HT) and kynurenine pathways, which has significant consequences for neurodevelopment. The PI's specific aims are: 1) To determine whether maternal inflammation alters placental synthesis and fetal exposure of 5-HT and kynurenine-pathway compounds; 2) To characterize the inflammation-mediated alternations of TRP metabolism effects on fetal brain neurochemistry and postnatal brain structure; 3) To determine if genetic or pharmacological manipulations of placental TRP metabolic pathways in vivo can reduce inflammation effect on offspring brain development.

Funder

Funder

Department of Defense - Autism Research Program

Fiscal Year Funding

Fiscal Year Funding

535699

Current Award Period

Current Award Period

2013-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Altered placental tryptophan metabolism: A crucial molecular pathway for the fetal programming of neurodevelopmental disorders (External web link)

Institution

Institution

University of Southern California

State/Country

State/Country

California

Project Number

Project Number

AR120066

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Altered placental tryptophan metabolism: A crucial molecular pathway for the fetal programming of neurodevelopmental disorders | 0 | 2015 | AR120066
Altered placental tryptophan metabolism: A crucial molecular pathway for the fetal programming of neurodevelopmental disorders | 0 | 2014 | AR120066
Altered placental tryptophan metabolism: A crucial molecular pathway for the fetal programming of neurodevelopmental disorders | 0 | 2013 | AR120066

 
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