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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Vulnerability phenotypes and susceptibility to environmental toxicants: From organism to mechanism

Principal Investigator

Principal Investigator

Noble, Mark

Description

Description

In this project, Dr. Noble will test the hypotheses that genetically-based differences in oxidative status are associated with differences in vulnerability to physiological stressors in vitro and in vivo, with even greater increases in vulnerability to combinations of physiological stressors. Specifically, thimerosal and other vaccine adjuvants will be studied. The second part of the study will determine if these effects on a novel regulatory pathway called redox/Fyn/c-Cbl is a necessary mechanistic convergence for increases in vulnerability caused by a more oxidized metabolic status. These results will provide a better understanding of the biochemical effects and mechanisms of possible toxicity of vaccines and vaccine additives.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2008-2012

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SE. Support at least two studies to determine if there are subpopulations that are more susceptible to environmental exposures (e.g., immune challenges related to infections, vaccinations, or underlying autoimmune problems) by 2012. IACC Recommended Budget: $8,000,000 over 2 years.

Project Link

Project Link

Vulnerability phenotypes and susceptibility to environmental toxicants: From organism to mechanism (External web link)

Institution

Institution

University of Rochester

State/Country

State/Country

New York

Project Number

Project Number

4955

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Vulnerability phenotypes and susceptibility to environmental toxicants: From organism to mechanism | 93500 | 2010 | 4955
Vulnerability phenotypes and susceptibility to environmental toxicants: From organism to mechanism | 0 | 2009 | 4955
Vulnerability phenotypes and susceptibility to environmental toxicants: From organism to mechanism | 0 | 2011 | 4955
Vulnerability phenotypes and susceptibility to environmental toxicants: From organism to mechanism | 110000 | 2008 | 4955

 
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