Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Development of brain connectivity in autism

Principal Investigator

Principal Investigator

Castellanos, Francisco Xavier

Description

Description

The investigators have perfected a method that requires very short imaging periods (minutes) for measuring functional connectivity (defined as the degree of synchronization between distant brain regions) that they have shown to be exquisitely sensitive in detecting connectivity differences between typically-developing children, adolescents, and adults. Preliminary data indicates that this team can detect autism-related differences in functional connectivity in children with high-functioning autism who are between 8-14 years of age. Here, the investigators propose a two-year cross-sectional study to examine such measures of connectivity in young children (between 36 and 60 months of age) with autism spectrum disorder (ASD) compared to controls. A comparative analysis across cortical regions will allow the investigators to determine whether there is a regional bias that includes frontal cortex, which is most involved in processing social information. The investigators also have included the development of analytical and imaging technologies that will be broadly applicable across imaging sites. The study thus has the opportunity to expand greatly the capacity of neuroimaging research programs around the country to include ASD as a focus of their efforts.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2009-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

Development of brain connectivity in autism (External web link)

Institution

Institution

New York School of Medicine

State/Country

State/Country

New York

Project Number

Project Number

5665

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Development of brain connectivity in autism | 262100 | 2010 | 5665
Development of brain connectivity in autism | 312916 | 2009 | 5665
Development of brain connectivity in autism | 300000 | 2008 | 5665
Development of brain connectivity in autism | 0 | 2011 | 5665

 
Back to Top