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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Neurophysiological investigation of language acquisition in infants at risk for ASD

Principal Investigator

Principal Investigator

Seery, Anne

Description

Description

Although language impairment is common is ASD, it is unclear at what point language acquisition in individuals with ASD begins to diverge from the typical trajectory. Recent developmental studies of ASD suggest that impairment in language and other domains may be present by 12 months (Mitchell, et al., 2006), but behavioral measures have failed to find consistent deficits before this age. Neurophysiological measures, which can be more sensitive to dysfunction before 12 months, have not yet been used to study very early language processing in ASD. The current project will study auditory ERP longitudinally in infants at risk for developing ASD (HRA) or language impairment (HRL) along with low risk controls (LRC). Our preliminary work suggests that HRA infants fail to develop lateralized ERP response to speech stimuli at 9 and 12 months. Here, we will examine whether this atypical asymmetry persists over the second and third years of life and whether it is predictive of later symptoms of ASD or SLI. Additionally, we will use ERP to examine phonemic perceptual narrowing between 6 and 12 months to determine whether this is delayed in infants who are later diagnosed with ASD and whether it is predictive of later language ability in HRA infants as it is in typical development. Finally, we will examine whether atypical ERP response to speech between 6 and 12 months may act as a neurobiological risk marker for ASD diagnosis, helping us to detect ASD over the first year of life.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2010-2012

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Project Link

Project Link

Neurophysiological investigation of language acquisition in infants at risk for ASD (External web link)

Institution

Institution

Boston University

State/Country

State/Country

Massachusetts

Project Number

Project Number

7003

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Neurophysiological investigation of language acquisition in infants at risk for ASD | 28000 | 2010 | 7003
Neurophysiological investigation of language acquisition in infants at risk for ASD | 28000 | 2011 | 7003

 
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