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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Discordant monozygotic twins as a model for genetic-environmental interaction in autism

Principal Investigator

Principal Investigator

Feinberg, Andrew

Description

Description

While environmental factors likely play an important role in the development and evolution of autism, their specific mechanism and, most importantly, their gene targets are unknown. We intend to study mechanisms by which the environment influences autism by studies in the exciting new field of epigenetics that links genes, environment, and disease. Epigenetics is a form of hereditary information that does not involve DNA sequence (i.e., the genetic code), but it influences whether a gene is turned on (i.e., whether the code is read). A major component of epigenetics is DNA methylation, a chemical change in DNA that is reproduced during cell division and is associated with gene silencing. DNA methylation is affected by a variety of environmental factors including diet. We hypothesize that epigenetic abnormalities contribute to the etiology of autism, and that by studying these abnormalities we could better understand autism's clinical variability as well as identify genes that may undergo epigenetic change in some patients, and conventional mutations in the genetic code in others. A compelling argument in support of our hypothesis is that monozygotic (genetically identical) twins are often discordant for autism, i.e., there is marked disparity in the degree of autism, suggesting the importance of factors other than the DNA sequence, like DNA methylation. We will test this idea by studying DNA methylation in such monozygotic twins who are discordant for autism. As demonstrated in our preliminary findings, we have already discovered genes that are abnormally methylated in the more affected twin. We will then examine whether the identified epigenetic changes are relevant to most patients with autism, by determining whether the same genes show altered DNA in autistic subjects in the general population, compared to control individuals. We will also determine whether patients not showing altered DNA methylation in these genes have conventional DNA sequence changes in the same genes, potentially linking genetic and epigenetic alterations in autism. This project will combine novel and sensitive high-throughput epigenomics strategies developed by the Initiating Principal Investigator (PI), a pioneer in epigenetics, with detailed phenotypic analyses by the Partnering PI, a leader in the study of autism in genetic disorders. These studies should have immediate practical implications for autism diagnosis. In addition, this work raises the exciting possibility of discovering mechanisms for autism that might be treatable, since epigenetic changes are potentially reversible, unlike DNA sequence mutations.

Funder

Funder

Department of Defense - Autism Research Program

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2009-2012

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Project Link

Project Link

Discordant monozygotic twins as a model for genetic-environmental interaction in autism (External web link)

Institution

Institution

Johns Hopkins University

State/Country

State/Country

Maryland

Project Number

Project Number

AR080125

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Discordant monozygotic twins as a model for genetic-environmental interaction in autism | 0 | 2010 | AR080125
Discordant monozygotic twins as a model for genetic-environmental interaction in autism | 0 | 2010 | AR080125P1
Discordant monozygotic twins as a model for genetic-environmental interaction in autism | 0 | 2009 | AR080125
Discordant monozygotic twins as a model for genetic-environmental interaction in autism | 0 | 2009 | AR080125P1
Discordant monozygotic twins as a model for genetic-environmental interaction in autism | 0 | 2011 | AR080125
Discordant monozygotic twins as a model for genetic-environmental interaction in autism | 0 | 2011 | AR080125P1
Discordant monozygotic twins as a model for genetic-environmental interaction in autism | 0 | 2012 | AR080125P1

 
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