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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

UC Davis Center for Children's Environmental Health (CCEH) Bridge

Principal Investigator

Principal Investigator

Pessah, Isaac

Description

Description

Immune system dysfunctions may represent one of the causes or phenotypes of autism spectrum disorders. Recently, investigators at the Children's Center for Environmental Health (CCEH) at University of California, Davis, demonstrated that some families affected by autism show disruptions in immune system signaling. This includes the presence of an abnormal antibody in the blood of a subset of mothers with an affected child, as well as disrupted immunological profiles of immune markers in some children who are affected. The CCEH has been investigating the mechanism by which environmental factors interact with the immune system to result in developmental disorders, including ASD. In order to complete key experiments focused on the flame retardants PBDEs (Polybrominated diphenyl ethers) and how they interact with the immune system to produce deleterious effects during development, two lines of investigation are key: the outcomes of animals exposed to PBDE during gestation, focusing on behavioral endpoints relevant to autism and immunohistochemical findings; and the immune response in blood samples taken from children affected by autism and those not affected by autism in response to PBDEs. Better understanding of the mechanisms involved in disruption of the immune system in ASD, especially environmental factors which exacerbate or trigger an immune response, will not only identify modifiable risk factors, but better define the cellular mechanism by which this occurs for more targeted biomarkers.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

75000

Current Award Period

Current Award Period

2012-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report “Autism and the Environment: Challenges and Opportunities for Research” as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.

Project Link

Project Link

UC Davis Center for Children's Environmental Health (CCEH) Bridge (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

7997

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

UC Davis Center for Children's Environmental Health (CCEH) Bridge | 0 | 2013 | 7997

 
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