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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Identifying therapeutic targets for autism using Shank3-deficient mice (supplement)

Principal Investigator

Principal Investigator

Buxbaum, Joseph

Description

Description

This is a supplement to project. Deletions and mutations of SHANK3 (a central player in synapse functioning) have been shown to lead to autism spectrum disorders (ASDs). This research makes use of Shank3-deficient mice to study Shank3 function in situ, as a model for SHANK3-haploinsufficiency (when there is only a single functional copy of a gene). The studies in this proposal are designed to gain a molecular and systems level understanding of Shank3 function and will identify molecular targets for novel therapeutics in human SHANK3-haploinsufficiency and in autism spectrum disorders.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

121077

Current Award Period

Current Award Period

2012-2013

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Identifying therapeutic targets for autism using Shank3-deficient mice (supplement) (External web link)

Institution

Institution

Mount Sinai School of Medicine

State/Country

State/Country

New York

Project Number

Project Number

3R01MH093725-02S1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Identifying therapeutic targets for autism using SHANK3-deficient mice | 483773 | 2011 | 1R01MH093725-01
Identifying therapeutic targets for autism using Shank3-deficient mice | 484667 | 2012 | 5R01MH093725-02

 
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