Autism Research Database - Strategic Plan Objective Project Details | IACC

Project Element	Element Description
Project Title Project Title	Assessing sleep regulation, sleep-dependent memory consolidation, and sleep-dependent synaptic plasticity in mouse genetic models of schizophrenia and autism spectrum disorders
Principal Investigator Principal Investigator	Aton, Sara J.
Description Description	Sara J. Aton, Ph.D., of the University of Pennsylvania, will study the effects of sleep abnormalities on cognitive functions in schizophrenia and autism spectrum disorders. Sleep loss is known to have detrimental effects on cognitive function and on synaptic plasticity, the neural mechanism underlying learning and memory. Using mouse models, Dr. Aton will assess how sleep, sleep-mediated plasticity, and sleep-dependent memory consolidation are affected by genetic mutations associated with schizophrenia and autism. These studies will improve understanding of sleep-dependent consolidation mechanisms under normal and pathological conditions, and clarify the contribution of sleep deficits to the etiology of autism spectrum disorders and schizophrenia.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	$45,000
Current Award Period Current Award Period	2010-2013
Strategic Plan Question Strategic Plan Question	Question 2: How Can I Understand What Is Happening?
Strategic Plan Objective Strategic Plan Objective	Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012.
Subcategory Subcategory	Co-occurring Conditions
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	University of Pennsylvania
Institute Location Institute Location	Pennsylvania
Project Number Project Number	N/A
Federal or Private Federal or Private	Private
History/Related Projects History/Related Projects	Assessing sleep regulation, sleep-dependent memory consolidation, and sleep-dependent synaptic plasticity in mouse genetic models of schizophrenia and autism spectrum disorders \| $0.00 \| 2011 \| N/A Assessing sleep regulation, sleep-dependent memory consolidation, and sleep-dependent synaptic plasticity in mouse genetic models of schizophrenia and autism spectrum disorders \| $32,469.00 \| 2013 \|

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