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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Evaluating epidemiological and biostatistical challenges in the EARLI investigation

Principal Investigator

Principal Investigator

Heavner, Karyn

Description

Description

This project will explore ways to more accurately determine environmental causes of autism using data from the Early Autism Risk Longitudinal Investigation (EARLI), a study of pregnant mothers who already have a child with autism spectrum disorders (ASD) and studying the environmental toxicants which they have been exposed to. Studies of this type are very difficult to conduct because even small errors in measurement of the potential toxin, the type of exposure or when it occurs can make a big difference in observed associations between the exposure and autism. Further complicating these studies, biological samples are taken from mothers and children in small amounts, making multiple tests difficult. The purpose of this project is twofold. First, we will examine how sensitive observed associations may be to small changes in measurement, with the goal of choosing the measurement strategies with the least amount of error. Second, we will develop strategies to test for the effects of multiple environmental exposures using the same biological sample, so as to conserve this finite resource. By conducting this type of methodological work early in the study, we will make much better use of limited resources and have much more confidence in our results. This will also provide guideline for others to study the environmental impacts on the development of autism.

Funder

Funder

Autism Science Foundation

Fiscal Year Funding

Fiscal Year Funding

40000

Current Award Period

Current Award Period

2012.0

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LA. Conduct a multi-site study of the subsequent pregnancies of 1,000 women with a child with ASD to assess the impact of environmental factors in a period most relevant to the progression of ASD by 2014. IACC Recommended Budget: $11,100,000 over 5 years.

Project Link

Project Link

Evaluating epidemiological and biostatistical challenges in the EARLI investigation (External web link)

Institution

Institution

Drexel University

State/Country

State/Country

Pennsylvania

Project Number

Project Number

N/A

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Evaluating epidemiological and biostatistical challenges in the EARLI investigation | 0 | 2013 | n/a

 
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