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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Center: Auditory perception and perceptual organization in minimally verbal children with ASD

Principal Investigator

Principal Investigator

Shinn-Cunningham, Barbara

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE). Studies of children and adults with ASD have shown that they process sensory information in atypical ways, though all prior research has focused on verbal individuals with ASD. In this project the hypothesis that minimally verbal children and adolescents with ASD cannot organize the auditory environment into meaningful units or objects will be explored. This may account for their profound deficits in spoken language ability. As suggested from other research, these atypical perceptual patterns may arise from abnormalities in anatomical and functional neural connectivity, which affects how neural regions interact during speech perception and production. Auditory processing and neural oscillations in three groups of 25 adolescents aged 14-17 with ASD, and varying in language level (minimally verbal, verbal but language impaired, and normal language) will be characterized using event-related potentials (ERP) and electroencephalography (EEG). ln addition, the ability for neural measures of auditory perception and neural oscillation patterns to predict response to a novel intervention for minimally verbal children will be assessed (tested in another project conducted by this ACE Center: 1P50DC013027-01, Sub-Project ID: 6023), as well as whether these measures show changes as a measure of intervention success. Together, the studies to be conducted in this project will advance understanding of the mechanisms that underlie language variation in ASD and may provide an explanation for why some children fail to acquire spoken language.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

288440

Current Award Period

Current Award Period

2012-2017

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2LB. Launch at least three studies which evaluate the applicability of ASD phenotype and/or biological signature findings for performing diagnosis, risk assessment, or clinical intervention by 2015. IACC Recommended Budget: $7,200,000 over 5 years.

Project Link

Project Link

ACE Center: Auditory perception and perceptual organization in minimally verbal children with ASD (External web link)

Institution

Institution

Boston University

State/Country

State/Country

Massachusetts

Project Number

Project Number

1P50DC013027-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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