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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The genetic control of social behavior in the mouse (supplement)

Principal Investigator

Principal Investigator

Blanchard, Robert

Description

Description

This is a supplement to project 5R01MH081845-04. This supplement provides funds for the examination of 5 pairs of age- and gender-matched post-mortem brain tissue specimens from the Autism Tissue Bank. The researcher will test the hypothesis that differences in the expression and/or regulation of heparan sulfate (HS, a protein found on the neuronal cell membrane) could significantly disrupt neural development, altering neurodevelopmental trajectories and contributing to the phenotypes associated with autism spectrum disorder (ASD). They will use a fluorescence immunohistochemical protocol to measure HS levels in brain tissue and perform microarray expression analysis on any HS-related genes found to be differentially expressed in patients vs healthy controls. The overall goals are to increase our understanding of the pathophysiological processes underlying ASD and to advance the development of heparan sulfate and/or HS-related genes as potential markers of ASD risk.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

201966

Current Award Period

Current Award Period

2012-2014

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

The genetic control of social behavior in the mouse (supplement) (External web link)

Institution

Institution

University of Hawai'i at Manoa

State/Country

State/Country

Hawaii

Project Number

Project Number

3R01MH081845-04S1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The genetic control of social behavior in the mouse | 342540 | 2011 | 5R01MH081845-03
The genetic control of social behavior in the mouse | 342540 | 2012 | 5R01MH081845-04

 
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