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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Novel metabolic biomarker for autism spectrum disorder

Principal Investigator

Principal Investigator

Schwartz, Charles

Description

Description

The goal of this project is to develop a screening tool for Autism Spectrum Disorder (ASD). These researcher's preliminary work using microarray plates, identified significantly lower levels of Nicotinamide Adenine Dinucleotide (NADH) in lymphoblasts generated in the presence of tryptophan in patients with ASD when compared to controls. The proposal for the current project is to first validate the preliminary findings using a cohort of 50 additional ASD patients and 50 additional controls, and to utilize the same metabolic profiling approach using leukocytes from fresh blood samples to determine if ASD can be quickly and reliably distinguished from controls. If the preliminary findings in lymphoblasts are confirmed in leukocytes, we would be able to develop a reliable, easy to perform, inexpensive laboratory test which could provide a diagnosis in about 4-5 days. Such a test could represent the first biochemical screening test for ASDs.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

148327

Current Award Period

Current Award Period

2012-2014

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1SE. Conduct at least one study to determine the positive predictive value and clinical utility (e.g., prediction of co-occurring conditions, family planning) of chromosomal microarray genetic testing for detecting genetic diagnoses for ASD in a clinical setting by 2012. IACC Recommended Budget: $9,600,000 over 5 years.

Project Link

Project Link

Novel metabolic biomarker for autism spectrum disorder (External web link)

Institution

Institution

Greenwood Genetic Center

State/Country

State/Country

South Carolina

Project Number

Project Number

1R21HD072473-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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