This is a Clinical Investigator Award, providing an opportunity for a medical investigator to develop into an independent researcher. There is now extensive evidence that functional connectivity abnormalities between brain regions are present in autism, which continue to develop through childhood and adolescence. These connectivity abnormalities comprise a promising technique for identifying autism subtypes, predicting prognosis, and guiding treatment. This project will conduct longitudinal neuroimaging studies of functional magnetic resonance connectivity in autism. The longitudinal design will allow assessment of how these connectivity abnormalities develop through late childhood and adolescence, and will leverage the largest imaging dataset of high-functioning autism DTI (diffusion tensor imaging) and volumetric scans from late childhood to early adulthood, allowing cross-modality analysis of brain connectivity.