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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A study of autism

Principal Investigator

Principal Investigator

Krieger, Abba

Description

Description

The Simons Simplex Collection, a repository of data on 2,000 families affected by autism, is a rich source of information for epidemiologic studies. However, because the data are collected at numerous institutions using a variety of methods, detecting meaningful trends across the entire collection will require serious statistical firepower. Abba Krieger and his colleagues at the University of Pennsylvania’s Wharton School plan to undertake this arduous task. The data — collected from children with autism, their parents and unaffected siblings — include demographics, medical histories of the affected children and their families, and results of various social and intelligence tests. Krieger has assembled a team of statisticians, mathematicians, bioinformatics experts and other researchers to review the data for accuracy, standardize it, and organize it into forms that are useful for statistical analyses. The researchers propose to comb the data for relationships between autism and demographic and environmental variables, and explore associations between data from the affected children and their family members. The researchers also plan to look for ‘clusters’ of individuals with similar data, which might provide insight into the variety of disorders that make up the autism spectrum. The analyses may also turn up variables or combinations of variables that are useful in predicting disease outcomes. Besides contributing to the understanding of autism and its causes, findings from this study may lead to the development of new statistical tools, and applications for handling large and diverse collections of data.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

162232

Current Award Period

Current Award Period

2008-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2LB. Launch at least three studies which evaluate the applicability of ASD phenotype and/or biological signature findings for performing diagnosis, risk assessment, or clinical intervention by 2015. IACC Recommended Budget: $7,200,000 over 5 years.

Project Link

Project Link

A study of autism (External web link)

Institution

Institution

University of Pennsylvania

State/Country

State/Country

Pennsylvania

Project Number

Project Number

121221

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A study of autism | 108701 | 2009 | 121221
A study of autism | 291461 | 2010 | 121221
A study of autism | 217402 | 2008 | Project number unavailable
A study of autism | 162232 | 2011 | 121221
A study of autism | 0 | 2013 | 121221

 
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