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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Center: Neuroimaging signatures of autism: Linking brain function to genes and behavior

Principal Investigator

Principal Investigator

Dapretto, Mirella

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE). Autism is characterized by tremendous phenotypic heterogeneity likely due to its complex genetic and neural underpinnings. There is mounting evidence of decreased responsivity to social stimuli and altered patterns of brain connectivity in individuals with autism specrum disorders (ASD), and aberrant functional and structural connectivity is related to genetic vulnerability to the disorder. This project will systematically chart longitudinal changes in brain activity and connectivity in children with and without ASD, relating the observed developmental trajectories to both behavioral phenotypes and autism risk genes. More specifically, using a longitudinal design, functional magnetic resonance imaging (fMRI), resting-state fMRI (rs-fMRI) and diffusion tensor imaging (DTI) will be performed at two timepoints (3 years apart) in two previously characterized age cohorts, and relate these data to behavioral phenotypes and ASD risk polymorphisms. This integrated research approach will identify the earliest departures from typical development and delineate the complex interactions among genes, brain, and behavior that drive development of ASD.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

191823

Current Award Period

Current Award Period

2012-2017

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

ACE Center: Neuroimaging signatures of autism: Linking brain function to genes and behavior (External web link)

Institution

Institution

University of California, Los Angeles

State/Country

State/Country

California

Project Number

Project Number

2P50HD055784-06

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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