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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

2/3-Multisite RCT of early intervention for spoken communication in autism

Principal Investigator

Principal Investigator

Smith, Tristram

Description

Description

While significant progress has been made toward identifying effective interventions for preschool-age children with autism, few scientifically rigorous studies have compared the essential elements of these interventions or examined outcomes focused on core deficits. To address these areas of need, this collaborative, multi-site project combines the expertise of investigators experienced in randomized controlled clinical trials (RCTs), in the study of core deficits in young children with autism, and in data management and analysis of multi-site clinical trials. The goal of this project is to compare the efficacy of two interventions for improving spoken language and reducing symptoms of autism: (1) Discrete trial training (DTT), which is an applied behavior analysis approach emphasizing learning readiness skills and (2) Interpersonal developmental approach (IDA), which is a child-focused approach that focuses on social engagement. Each site will recruit 64 children with autism, 3-4 years of age, who are engaged in 25 hour per week early intervention programs. This intervention will be augmented with two 30-minute sessions daily of the study intervention (DTT or IDA) conducted by supervised therapists for 4 months, with transition to home therapy for 2 months. The primary aims are to compare intervention conditions (DTT and IDA) on child outcomes of spoken language and core deficits of social features of autism both at the end of treatment and 6 months later, as well as to examine potential moderators (e.g., mental age, language age) on treatment outcome. Secondary exploratory analyses focus on potential mediators (parent synchronization of joint attention and changes in parental expectancies) and non-specific factors (quality and quantity of community treatment).

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

391019

Current Award Period

Current Award Period

2009-2014

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SF. Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups: o Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years. o Three trials in school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years. o Three trials in adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.

Project Link

Project Link

2/3-Multisite RCT of early intervention for spoken communication in autism (External web link)

Institution

Institution

University of Rochester

State/Country

State/Country

New York

Project Number

Project Number

5R01MH084870-04

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

2/3-Multisite RCT of early intervention for spoken communication in autism | 392336 | 2011 | 5R01MH084870-03

 
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