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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Revealing protein synthesis defects in fragile X syndrome with new chemical tools

Principal Investigator

Principal Investigator

Lin, Michael

Description

Description

Fragile X syndrome is the most common genetic cause of autism and mental retardation. It is caused by a mutation in the gene for the Fragile X mental retardation protein (FMRP), which is required for regulating protein synthesis at synapses. This proposal will apply new molecular tools to reveal the molecular basis of the learning and emotional symptoms in fragile X syndrome. These tools will allow the real-time tracking and control of new protein synthesis and the visualization of kinase pathways involved in activity-induced protein synthesis. The specificity of protein synthesis responses in synaptic strengthening versus weakening, the proteins required for long-lasting synaptic plasticity, and how FMRP loss might alter these processes will be studied. This knowledge will be useful in identifying possible targets for the development of drugs to treat fragile X syndrome and potentially other autism spectrum disorders.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

340520

Current Award Period

Current Award Period

2011-2015

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Revealing protein synthesis defects in fragile X syndrome with new chemical tools (External web link)

Institution

Institution

Stanford University

State/Country

State/Country

California

Project Number

Project Number

5R01NS076860-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Revealing protein synthesis defects in fragile X syndrome with new chemical tools | 315341 | 2011 | 1R01NS076860-01

 
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