This project investigates the relevance of newly discovered components of ion channels in brain neurons that are important in learning, pain control, and the pathogenesis of epilepsy and autism. Fast transient potassium currents, such as those found in neurons and cardiac cells, are essential for the proper functioning of the brain and the heart. During pathological conditions, abnormalities in these currents can contribute to disease conditions. This project addresses the molecular nature of the ion channels responsible for the generation of these currents in mammalian neurons, using both cellular and mouse models. It seeks to establish the molecular composition of these channels and to elucidate the physiological significance of the identified components.