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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Mechanisms of valproic acid-induced neurodevelopmental and behavioral defects

Principal Investigator

Principal Investigator

Krueger, Bruce

Description

Description

Valproic acid (VPA), a widely-used antiepileptic and mood stabilizing drug, causes neurodevelopmental defects in children of women exposed during pregnancy. Based on novel preliminary results generated by the researchers, it is postulated that VPA stimulates the expression of the neurotrophin, brain-derived neurotrophic factor (BDNF), by epigenetic desilencing of the BDNF gene, leading to defective brain development and consequently abnormal behavior. The goal of this research is to determine the mechanism by which fetal exposure to a clinically used agent, VPA, induces neurodevelopmental defects. This will be accomplished utilizing a novel transgenic mouse. This would enable the identification of signaling pathways that can be targeted to avoid adverse neurodevelopmental effects in pregnant women who require VPA for control of epilepsy and bipolar disorder.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

318513

Current Award Period

Current Award Period

2012-2017

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Project Link

Project Link

Mechanisms of valproic acid-induced neurodevelopmental and behavioral defects (External web link)

Institution

Institution

University of Maryland, Baltimore

State/Country

State/Country

Maryland

Project Number

Project Number

1R01HD067135-01A1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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