Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Center: Testing the efficacy of a novel intervention for minimally verbal children with ASD

Principal Investigator

Principal Investigator

Schlaug, Gottfried

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE). Although up to 30% of individuals with autism spectrum disorder (ASD) are minimally verbal, extremely few interventions can reliably produce significant improvements in speech output. Recently, the researchers involved in this project have developed Auditory-Motor Mapping Training (AMMT), a novel intonation-based intervention, which aims to facilitate speech output in minimally verbal children with ASD. This intervention involves the mapping of sounds to oral articulatory actions through intonation and bimanual motor activities and is built upon the musical strengths and preferences that have been observed in these children. Furthermore, associating sounds with actions engages an auditory-motor network of brain regions important for speech that has been reported to be dysfunctional in ASD. The overall aim of the study is to compare the efficacy of AMMT to that of a control therapy (CT) in facilitating speech output in a randomized controlled trial (RCT). In addition, the effect of frequency of AMMT on treatment outcome, and whether pre-existing variability in language-related pathways and functional connections correlate with outcome and is changed after treatment, will be examined. By using a combination of behavioral and brain imaging measures, the proposed study will examine the efficacy of a novel intervention and enhance understanding of the underlying neural mechanisms that underlie the therapy effects.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

377590

Current Award Period

Current Award Period

2012-2017

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SG. Support at least five studies on interventions for nonverbal individuals with ASD by 2012. Such studies may include: o Projects examining service-provision models that enhance access to augmentative and alternative communication (AAC) supports in both classroom and adult service-provision settings, such as residential service-provision and the impact of such access on quality of life, communication, and behavior; o Studies of novel treatment approaches that facilitate communication skills in individuals who are nonverbal, including the components of effective AAC approaches for specific subpopulations of people with ASD; and o Studies assessing access and use of AAC for children and adults with ASD who have limited or partially limited speech and the impact on functional outcomes and quality of life. IACC Recommended Budget: $3,000,000 over 2 years.

Project Link

Project Link

ACE Center: Testing the efficacy of a novel intervention for minimally verbal children with ASD (External web link)

Institution

Institution

Boston University

State/Country

State/Country

Massachusetts

Project Number

Project Number

1P50DC013027-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
Back to Top