Fragile X syndrome (FXS) is a developmental brain disorder with abnormal neuron architecture and functional plasticity of the developing brain. It is the most commonly inherited form of both mental retardation and autism spectrum disorders (ASD). The proposed research will use the fruit fly as a model organism to study the molecular and cellular basis of disease, focusing particularly on the role of the Fragile X Mental Retardation Protein (FMRP). Previous research by this lab showed that human FMRP leads to total functional conservation in this model. Moving forward, this project aims to test core hypotheses regarding the molecular mechanisms relating to FMRP loss and test interventions to correct the resultant developmental brain defects.