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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Genetic and developmental analyses of fragile X mental retardation protein

Principal Investigator

Principal Investigator

Broadie, Kendal

Description

Description

Fragile X syndrome (FXS) is a developmental brain disorder with abnormal neuron architecture and functional plasticity of the developing brain. It is the most commonly inherited form of both mental retardation and autism spectrum disorders (ASD). The proposed research will use the fruit fly as a model organism to study the molecular and cellular basis of disease, focusing particularly on the role of the Fragile X Mental Retardation Protein (FMRP). Previous research by this lab showed that human FMRP leads to total functional conservation in this model. Moving forward, this project aims to test core hypotheses regarding the molecular mechanisms relating to FMRP loss and test interventions to correct the resultant developmental brain defects.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

438391

Current Award Period

Current Award Period

2011-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Genetic and developmental analyses of fragile X mental retardation protein (External web link)

Institution

Institution

Vanderbilt University Medical Center

State/Country

State/Country

Tennessee

Project Number

Project Number

2R01MH084989-03A1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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