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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Population-based autism genetics & environment study

Principal Investigator

Principal Investigator

Buxbaum, Joseph

Description

Description

While there has been great progress in understanding the risks contributing to autism spectrum disorders (ASD), there are still unanswered questions about the nature of the genetic and non-genetic risks for autism. Many of these questions can be best addressed with a population-based epidemiological sample with detailed demographic and environmental information. Epidemiologically based samples provide a unique resource to identify genetic and non-genetic causes of autism, while allowing for a precise estimate of risk in the population. Sweden benefits from a centralized medical system that has been the foundation of large-scale epidemiological studies in psychiatric disorders, particularly schizophrenia and bipolar disorder. This study presents a unique, population-based epidemiological sample in Sweden that will be evaluated for estimations of heritability and identification of rare, genetic variation conferring risk to autism, while providing an integrated model for genetics and environment in autism. This project aims to provide the groundwork for understanding shared risk across autism and schizophrenia, making use of a specific human population that permits identification of shared risk. This approach addresses many of the open questions in autism research and provides a path towards a better understanding of the risk factors for autism and ultimately to better interventions in autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

723934

Current Award Period

Current Award Period

2012-2014

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LD. Support ancillary studies within one or more large-scale, population-based surveillance and epidemiological studies, including U.S. populations, to collect data on environmental factors during preconception, and during prenatal and early postnatal development, as well as genetic data, that could be pooled (as needed), to analyze targets for potential gene/environment interactions by 2015. IACC Recommended Budget: $44,400,000 over 5 years.

Project Link

Project Link

Population-based autism genetics & environment study (External web link)

Institution

Institution

Mount Sinai School of Medicine

State/Country

State/Country

New York

Project Number

Project Number

1R56MH097849-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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