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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The roles of environmental risks and GEX in increasing ASD prevalence

Principal Investigator

Principal Investigator

Kim, Young Shin

Description

Description

Progressive increases in Autism Spectrum Disorders (ASD) prevalence, from 0.07 to 2.64%, represent a significant public health concern. It remains unclear whether changes in ASD incidence are contributing to such increased rates of ASD; this uncertainty may lend credence to concerns that environmental factors and gene-environmental interactions (GEX) are increasing the risks for ASD. Detecting the causes of ASD has proven to be challenging for many reasons, including the complexity of ASD genetics and GEX, as well as the difficulty in doing adequately designed studies. This proposal will use a very large, total population study of children with ASD, their families and matched controls, to identify some causes of ASD by first estimating ASD cumulative incidence and then examining the roles of environmental factors and GEX in creating risks for ASD.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

575290

Current Award Period

Current Award Period

2012-2017

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LD. Support ancillary studies within one or more large-scale, population-based surveillance and epidemiological studies, including U.S. populations, to collect data on environmental factors during preconception, and during prenatal and early postnatal development, as well as genetic data, that could be pooled (as needed), to analyze targets for potential gene/environment interactions by 2015. IACC Recommended Budget: $44,400,000 over 5 years.

Project Link

Project Link

The roles of environmental risks and GEX in increasing ASD prevalence (External web link)

Institution

Institution

Yale University

State/Country

State/Country

Connecticut

Project Number

Project Number

1R01ES021462-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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