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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Autism risk, prenatal environmental exposures, and pathophysiologic markers

Principal Investigator

Principal Investigator

Hertz-Picciotto, Irva

Description

Description

This study, known as MARBLES (Markers of Autism Risk in Babies - Learning Early Signs), addresses both the causes and the mechanisms of autism spectrum disorders (ASDs). The aim is to determine the role for two classes of common household chemical exposures, namely pyrethroid pesticides and brominated flame retardants, using an innovative design that maximizes the efficiency of the study. Additionally, MARBLES will explore the role of maternal immune dysregulation and of mitochondrial dysfunction in the newborn as markers of potential mechanisms leading to aberrant neurodevelopment. By addressing both the need to understand risk factors for ASDs beginning during gestation and the need to elucidate underlying mechanisms, MARBLES has the ability to move the field of autism forward towards a more multifactorial and mechanistically driven research agenda. From this study, interventions at the individual behavioral or societal level may be suggested.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

1815424

Current Award Period

Current Award Period

2011-2016

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SC. Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.

Project Link

Project Link

Autism risk, prenatal environmental exposures, and pathophysiologic markers (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

5R01ES020392-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Autism risk, prenatal environmental exposures, and pathophysiologic markers | 1858222 | 2011 | 1R01ES020392-01

 
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