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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Genome-wide identification of variants affecting early human brain development

Principal Investigator

Principal Investigator

Santelli, Rebecca

Description

Description

The primary goal of the current project is to identify common and rare genetic variants which predict early brain development in humans; a period which may be critical in the development of psychiatric and neurodevelopmental disorders such as autism, schizophrenia, intellectual disability and attention-deficit disorder. Using brain imaging in combination with genotyping, this study aims to examine whether variation in structural brain phenotypes is predicted by different genetic variants. While the focus of this grant is on the neonatal period, participants are also returning for follow-up scans and detailed developmental assessments at 1, 2, 4 and 6 yrs of age. Identifying the genes involved in brain development has the potential to significantly improve diagnosis, guide research efforts into environmental risk factors, and generate completely new treatment possibilities for individuals with psychiatric and neurodevelopmental conditions.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

611005

Current Award Period

Current Award Period

2011-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

Genome-wide identification of variants affecting early human brain development (External web link)

Institution

Institution

University of North Carolina at Chapel Hill

State/Country

State/Country

North Carolina

Project Number

Project Number

5R01MH092335-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Genome-wide identification of variants affecting early human brain development | 504632 | 2011 | 1R01MH092335-01A1

 
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