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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Network: Early biomarkers of autism spectrum disorders in infants with tuberous sclerosis

Principal Investigator

Principal Investigator

Sahin, Mustafa

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE) Network. Studying infants with Tuberous Sclerosis Complex (TSC), is a genetic disorder with a high prevalence of autism spectrum disorder (ASD). Because TSC can be diagnosed before or at the time of birth, there is the potential to develop better tools for early detection of ASD. This project will investigate whether longitudinal assessment of brain connectivity using magnetic resonance imaging (MRI) and electroencephalography (EEG) in children with TSC can identify an early biomarker of subsequent ASD in this genetic disease. This study will establish a consortium of five Children's Hospitals that are geographically-distributed throughout the United States to recruit TSC patients in the first year of life to test this hypothesis. State of the art imaging with 3 Tesla MRI scanners, advanced EEG technology, validated neurodevelopmental assessment tools, genetic analysis, and standardized clinical measures through age 36 months will be utilized. The clinical consortium will be supported by a centralized Data Coordinating Center with experience in another rare disease (neurofibro- matosis). Collaboration with Leadership Education in Neurodevelopmental and Related Disabilities (LEND) programs at each center will provide additional interdisciplinary research training and education expertise in ASD and TSC. As a result of the research outlined in this proposal, better understanding of brain connectivity and it relationship to ASD in TSC will pave the way for new interventions for this and related causes of ASD.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

2649781

Current Award Period

Current Award Period

2012-2017

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Project Link

Project Link

ACE Network: Early biomarkers of autism spectrum disorders in infants with tuberous sclerosis (External web link)

Institution

Institution

Boston Children's Hospital

State/Country

State/Country

Massachusetts

Project Number

Project Number

1U01NS082320-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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