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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Gene-environment interactions in an autism birth cohort

Principal Investigator

Principal Investigator

Lipkin, W. Ian

Description

Description

Reports of increasing prevalence of autism spectrum disorders (ASDs) are intensifying interest in the role of environmental exposures, including infectious, immune, and toxic factors. This prospective study will employ the Autism Birth Cohort (ABC), a smaller cohort (ASD, N=150-233) selected from the Norway Mothers and Child (MoBa) study, which consists of 75,500 Norwegian mother-child pairs. In the ABC study, children meeting criteria for an autism diagnosis are ascertained through screening of the entire population with diagnoses established using uniform procedures. In addition to an autism diagnosis, extensive histories and clinical data are obtained and biologic samples are collected serially throughout pregnancy and early childhood. Researchers in this study aim to identify gene-environment factors contributing to the development of autism, including: 1) immune, endocrine, and neuroregulatory factors in mothers during early gestation or at birth, 2) environmental factors, including pre- or postnatal infection, vaccination, very low birth weight or other obstetric risk factors, dietary and/or environmental exposure to methylmercury, and 3) genotypic influences that are associated with a family history of autoimmune disease or other ASD candidate genes. The Norwegian ABC study offers an unprecedented, rich view of the longitudinal trajectory and nascent signs and symptoms of autism spectrum disorders, facilitating discovery of biomarkers and gene-environment interactions in ASD pathogenesis.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

3012046

Current Award Period

Current Award Period

2011-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LD. Support ancillary studies within one or more large-scale, population-based surveillance and epidemiological studies, including U.S. populations, to collect data on environmental factors during preconception, and during prenatal and early postnatal development, as well as genetic data, that could be pooled (as needed), to analyze targets for potential gene/environment interactions by 2015. IACC Recommended Budget: $44,400,000 over 5 years.

Project Link

Project Link

Gene-environment interactions in an autism birth cohort (External web link)

Institution

Institution

Columbia University

State/Country

State/Country

New York

Project Number

Project Number

5U01NS047537-07

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Gene-environment interactions in an autism birth cohort | 3183066 | 2011 | 2U01NS047537-06A1

 
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