Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Network: Multimodal developmental neurogenetics of females with ASD

Principal Investigator

Principal Investigator

Pelphrey, Kevin

Description

Description

It has repeatedly been observed that autism spectrum disorders (ASD) disproportionately affect males relative to females. Although many hypotheses attempt to explain this bias, no clear answers have emerged due to inconsistent and incomplete characterization and small sample sizes. This study seeks to examine sex- specific differences in individuals with ASD using methods including deep phenotyping and genotyping. Researchers will quantitatively phenotype multiple behavioral domains and measure several key ASD-related neural systems at the level of brain structure, connectivity, and function. Additionally, investigators will measure copy number variation (CNV) and single nucleotide variation (SNV) for these participants and their parents, which will allow for the testing of sex- and circuit-specific genotype-phenotype hypotheses. Through this study, investigators will Identify sex-differences in brain mechanisms underlying ASD, search for relationships between brain mechanisms and underlying genetic differences, and determine the mechanisms underlying heterogeneity in the presentation and severity of ASD in boys and girls.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

3118985

Current Award Period

Current Award Period

2012-2017

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SB. Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years.

Project Link

Project Link

ACE Network: Multimodal developmental neurogenetics of females with ASD (External web link)

Institution

Institution

Yale University

State/Country

State/Country

Connecticut

Project Number

Project Number

1R01MH100028-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
Back to Top