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Question 4: Objective 5
Q4.5 : Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.
Projects Found: 42
Total Funding: $15,879,827
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Autism Consortium Models and mechanisms - 2 $90,000
$90,000 Boston Children's Hospital
National Institutes of Health Genetic analyses of ARX homeobox gene function in neurodevelopmental disorders $211,950
$211,950 Brandeis University
Autism Research Institute Oxidative stress: Rat study $40,000
$40,000 Brigham and Women's Hospital
Simons Foundation A non-human primate autism model based on maternal infection $446,873
$446,873 California Institute of Technology
Simons Foundation Cellular and molecular alterations in gabaergic inhibitory circuits by mutations in MECP2, a gene implicated in the Rett syndrome of the autism spectrum disorders $441,032
$441,032 Cold Spring Harbor Laboratory
Simons Foundation Novel models to define the genetic basis of autism $800,694
$800,694 Cold Spring Harbor Laboratory
Simons Foundation Aberrant synaptic function due to TSC mutation in autism $150,000
$150,000 Columbia University Medical Center
National Institutes of Health Distinct function of the neuroligin 3 postsynaptic adhesion complex $45,972
$45,972 Columbia University
National Institutes of Health Cognitive mechanisms of serially organized behavior $307,187
$307,187 Columbia University
National Institutes of Health Molecular determinants of L-type calcium channel gating $402,500
$402,500 Columbia University
Interagency Autism Coordinating Committee (IACC)
Autism Research Database (AFD)
Q4.5: Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. 
