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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Anti-Neuronal Autoantibodies in PANDAS and Autism Spectrum Disorders

Principal Investigator

Principal Investigator

Cunningham, Madeleine

Description

Description

Pediatric neuropsychiatric and movement disorders affect millions of children each year with devastating consequences on families. Work done over the past 12+ years has focused on understanding how infections and autoantibody responses affect the brain. The investigators have found that neuropsychiatric and movement disorders such as pediatric autoimmune neuropsychiatric disorder associated with streptococci (PANDAS) are associated with a group of autoantibodies which may be elevated during disease symptoms and may signal neuronal cells in the brain. This project explores the hypothesis that autism spectrum disorders (ASD) are associated in some instances with PANDAS symptoms where the two diseases may be co-morbid. ASDs are characterized by deficits in social communication and restrictive and repetitive interests and behaviors, and many children with ASD also have intellectual and developmental disabilities. Children diagnosed with ASD can exhibit symptoms associated with other childhood neuropsychiatric disorders such as ADHD, OCD and depression. Specific aims of this proposal include: evaluating and confirming an existing sample of 47 children with autism who demonstrated an acute onset of OCD and/or tic symptoms associated with PANDAS; careful characterization of a general sample of 20-40 children with a firm diagnosis of ASD; and analyzing sera from these children to be analyzed for autoantibodies against neuronal antigens tubulin, lysoganglioside, and D1 and D2 dopamine receptors. Autism sera (IgG) also will be examined for signaling of human neuronal cells in culture. This project will study receptors on neuronal cells and on receptor transfected cells which may be signaled by autoantibodies in autistic sera and provoke altered behaviors in autism. This research has the potential to identify patients with autism who would benefit from immunotherapies or other PANDAS treatments. - See more at: http://science.grants.autismspeaks.org/search/grants/anti-neuronal-autoantibodies-pandas-and-autism-spectrum-disorders#sthash.LFEOPX43.dpuf

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

100000

Current Award Period

Current Award Period

2013-2014

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Anti-Neuronal Autoantibodies in PANDAS and Autism Spectrum Disorders (External web link)

Institution

Institution

University of Oklahoma Health Sciences Center

State/Country

State/Country

Oklahoma

Project Number

Project Number

8624

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Anti-Neuronal Autoantibodies in PANDAS and Autism Spectrum Disorders | 0 | 2014 | 8624

 
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