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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Anti-Neuronal Autoantibodies against Bacterial Polysaccharides in Autism Spectrum Disorders

Principal Investigator

Principal Investigator

Cunningham, Madeleine

Description

Description

Autoantibodies against brain and bacterial polysaccharides are not well characterized in Autism Spectrum Disorders (ASD). Anti-streptococcal autoantibodies are well characterized in Rheumatic Fever and Sydenham chorea (SC) by human monoclonal antibodies (mAbs) and Immunoglobulin G (IgG) derived from SC. SC is a prototype movement and neuropsychiatric disorder recognized for autoimmunity developing from a bacterial infection. Other bacterial polysaccharides may play an important role in crossreactivity with brain such as in Streptococcus pneumoniae and Haemophilus influenzae type b. These studies are expected to determine potential antibody risk factors and potentially diagnostic tools to subset Autistic children for better diagnosis scales and more effective treatment if immune dysregulation is the underlying cause of some of their symptoms.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

100000

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Anti-Neuronal Autoantibodies against Bacterial Polysaccharides in Autism Spectrum Disorders (External web link)

Institution

Institution

University of Oklahoma Health Sciences Center

State/Country

State/Country

Oklahoma

Project Number

Project Number

9535

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Anti-Neuronal Autoantibodies against Bacterial Polysaccharides in Autism Spectrum Disorders | 0 | 2015 | 9535

 
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