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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The IL-17 pathway in the rodent model of autism spectrum disorder

Principal Investigator

Principal Investigator

Huh, Jun

Description

Description

Autism spectrum disorder (ASD) is one of the most prevalent and debilitating disorders for patients and their family members. Understanding the neural mechanisms of ASD will greatly facilitate the development of novel ways to prevent and treat ASD. Severe infection in mothers during pregnancy is correlated with increased incident of ASD in offspring. Consistent with human studies, maternal immune activation (MIA) model in rodents also induces autism-like phenotypes in offspring. Recently, our group demonstrated that the interleukin receptor 17a (IL- 17Ra) pathway is necessary for the development of cortical lamination and autism-like behavioral phenotypes in MIA offspring. Here, I propose to investigate the role of IL- 17Ra in the brain development of normal and MIA-affected offspring, as well as the mechanisms behind the abnormal cortical lamination seen in MIA offspring, focusing on neuronal migration. My first two goals for this experiment will be to characterize the adhesive properties of IL-17Ra during brain development, and then to identify binding partners of IL-17Ra during neuronal migration. I hope these results will demonstrate a novel role of the immune system in brain development and aid in the development of mechanism-based interventions for MIA-induced ASD.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

90000

Current Award Period

Current Award Period

2015-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

The IL-17 pathway in the rodent model of autism spectrum disorder (External web link)

Institution

Institution

University of Massachusetts, Worcester

State/Country

State/Country

Massachusetts

Project Number

Project Number

422632

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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