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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Primate models of autism

Principal Investigator

Principal Investigator

Bauman, Melissa

Description

Description

This project is designed to provide additional support for the hypothesis that abnormal maternal autoantibodies may be one cause of autism. The study will build on preliminary results in rhesus monkeys that tested prenatal exposure to immunoglobulin G (IgG) class antibodies against human fetal brain tissue. This study will expand the number of test subjects and also increase the time period of antibody exposure into the second trimester on some subjects. The monkeys will then be followed for at least two years, evaluating behavioral development and performing longitudinal magnetic resonance imaging (MRI) scans. If maternal autoantibodies are identified as a risk factor for autism, this finding would quickly lead both to the development of a diagnostic assay for maternal autoantibodies and to the development of therapeutic interventions to diminish this autism risk factor.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

724953

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.

Project Link

Project Link

Primate models of autism (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

5R01MH080218-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Primate models of autism | 734756 | 2010 | 5R01MH080218-03
Primate models of autism | 727322 | 2008 | R01MH080218-01A2

 
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