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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Transgenic mouse model to address heterogeneity in autism spectrum disorders

Principal Investigator

Principal Investigator

Blakely, Randy

Description

Description

Rare, functional gene variants that lead to hyperfunction of the serotonin transporter (SERT) have been associated with a specific subset of autism spectrum traits, rigid-compulsive behaviors and sensory aversion. A novel, transgenic mouse model expressing the most common of these SERT variants, Ala56, has been produced. Based on preliminary evidence that mice expressing Ala56 SERT exhibit multiple behavioral and biochemical phenotypes, this project will extend studies and dissect the impact of SERT hyperfunction in these animals. These studies will enhance understanding of the contributions of altered SERT activity and regulation to autism heterogeneity and provide a novel platform for the preclinical evaluation of therapeutic interventions.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

454745

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Transgenic mouse model to address heterogeneity in autism spectrum disorders (External web link)

Institution

Institution

Vanderbilt University

State/Country

State/Country

Tennessee

Project Number

Project Number

1R01HD065278-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Transgenic mouse model to address heterogeneity in autism spectrum disorders | 468586 | 2010 | 5R01HD065278-02

 
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