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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Maternal inflammation alters fetal brain development via tumor necrosis factor-alpha

Principal Investigator

Principal Investigator

Carpentier, Pamela

Description

Description

This is an individual National Research Service Award for post-doctoral research training, which provides support to promising fellowship applicants with the potential to become productive, independent investigators in scientific health-related research fields. In this proposed study, the fellow will examine the influence of maternal illness on the health of offspring. Maternal illness has been associated with a number of problems in brain development in the child, including autism and schizophrenia. The fellow will study a mouse model in which illness and inflammation in the pregnant mother has significant effects on the number and timing of neurons being born in the fetal brain. The goal of this study is to examine the mechanisms by which fetal brain development is altered in this model, focusing on the role of a single inflammatory molecule (TNF-alpha), which could be clinically targeted to prevent developmental diseases.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

12928

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.

Project Link

Project Link

Maternal inflammation alters fetal brain development via tumor necrosis factor-alpha (External web link)

Institution

Institution

Stanford University

State/Country

State/Country

California

Project Number

Project Number

5F32NS060427-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Maternal inflammation alters fetal brain development via Tumor Necrosis Factor-alpha | 49646 | 2008 | F32NS060427-01A1

 
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