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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Genetic study of restricted repetitive behavior in autism spectrum disorders

Principal Investigator

Principal Investigator

Kim, Soo-Jeong

Description

Description

As one of the core features of ASDs, restricted repetitive behavior (RRB) frequently dominates the daily activities of affected children, interferes with opportunities to develop functional behaviors, and requires intervention and treatment. The objective of this study is to identify contributing genetic factors for abnormal repetitive behavior (such as flapping arms, lining up objects, peculiar fascination with odd objects, a very narrow restricted interest, and intolerance to changes of routines) among children with autism spectrum disorders (ASDs). Researchers will investigate whether genetic variations within the GABA and glutamate neurotransmission system play a role in the pathogenesis of RRB in children with ASDs. Using behavioral rating scales, medical histories, and parental input, researchers will measure the extent of RRBs in children with ASD (ages 6-18). Biomaterials from these children, like saliva and buccal swabs, will be used to genotype GABA and glutamate system-related genes, allowing researchers to correlate genetic variants with RRB behavioral measures. Positive findings may lead to a new insight as to early detection and treatment of this chronic and disabling condition.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

72856

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Project Link

Project Link

Genetic study of restricted repetitive behavior in autism spectrum disorders (External web link)

Institution

Institution

University of Florida

State/Country

State/Country

Florida

Project Number

Project Number

5R03MH083673-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Genetic study of restricted repetitive behavior in autism spectrum disorders | 72907 | 2008 | R03MH083673-01

 
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