The goal of this project is to delineate the clinical and genetic heterogeneity within the Autism Spectrum Disorder diagnosis so that prognoses, treatments, and preventive strategies can be implemented which are specific to each autism subgroup. To aide clinicians in identification of complex autism, researchers developed the Autism Dysmorphology Measure (ADM) which directs the clinician, following a brief, clothed examination, to make a judgment of dysmorphic vs. nondysmorphic. Using this measure in the Simons Simplex Collection (SSC) is providing the first large-scale test of the ADM, including comparing ADM reliability by users with different levels of training and analyzing reliability of the ADM compared to a comprehensive dysmorphology examination. Comparing the ADM to a comprehensive dysmorphology examination by a geneticist has provided exceptional correlation (99% sensitivity; 100% specificity). In addition to enhancing previous associations, rigorously controlled SSC data allows identification of new associations, including use of the Social Responsiveness Scale (SRS) to study autism family loading in subgroups.