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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Human autism genetics and activity-dependent gene activation

Principal Investigator

Principal Investigator

Walsh, Christopher

Description

Description

Autism and autism spectrum disorders (ASD) are a group of neurological conditions characterized by impairment in the ability to communicate, form relationships, and respond appropriately to the environment. Previous approaches to autism genetics have each led to the discovery of specific genes, mutations and biological mechanisms that play a role in autism. Yet in sum, the genes identified still leave unexplained the vast majority of the heritability of autism in humans - and, presumably, important etiological mechanisms that might (if known) productively guide development and deployment of therapy and prevention. This study will use the latest genetic technologies, including whole exome and genome sequencing, to significantly increase our knowledge of the genetic causes of autism. The discovery of genes that contribute to autism is critical not only for earlier and better diagnosis but also for informing strategies for prevention and therapy.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

2474114

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Project Link

Project Link

Human autism genetics and activity-dependent gene activation (External web link)

Institution

Institution

Children's Hospital Boston

State/Country

State/Country

Massachusetts

Project Number

Project Number

1RC2MH089952-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

N/A

 
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