Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Early biologic markers for autism

Principal Investigator

Principal Investigator

Croen, Lisa

Description

Description

Proteins of the maternal immune system during pregnancy may be able to affect the development of the fetal brain, as these proteins can cross the placenta and enter fetal tissues. Preliminary results have provided evidence that elevated levels of certain immune system proteins in the blood of pregnant women may be associated with an increased risk of autism in their children. These researchers will extend their preliminary data by conducting a large controlled study on the association between levels of autoantibodies and cytokines in maternal blood samples during mid-pregnancy with the associated risks of autism and mental retardation in the offspring. 1200 mother-child pairs will be included in this study, as well as 200 siblings of autistic and mentally retarded children. These data will determine whether inappropriate activation of the immune system during pregnancy is associated with an increased risk of neurodevelopmental problems. The results from this study should contribute to the understanding of the impact of the maternal environment on fetal development and its contribution to autism. It may also provide new, early tests for an increased risk of autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

43308

Current Award Period

Current Award Period

2008-2010

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Early biologic markers for autism (External web link)

Institution

Institution

Kaiser Permanente Division of Research

State/Country

State/Country

California

Project Number

Project Number

2514

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Early biologic markers for autism | 60000 | 2009 | 2514
Early biologic markers for autism | 60000 | 2008 | 2514

 
Back to Top