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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Biological correlates of altered brain growth in autism

Principal Investigator

Principal Investigator

Vaccarino, Flora; Gerstein, Mark; Grigorenko, Elena; Weissman, Sherman

Description

Description

This project will develop lines of induced pluripotent stem cells (iPSC) from individuals with autism spectrum disorders (ASD) with macrocephaly and typically developing children, using cells obtained by a skin biopsy. Several iPSC lines per individual will be produced and characterized with respect to their biology and their structural genetic variation. The aim is create a resource and analytical tool, which will enable examination of neuronal differentiation in autism spectrum disorders.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

975783

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Project Link

Project Link

Biological correlates of altered brain growth in autism (External web link)

Institution

Institution

Yale University

State/Country

State/Country

Connecticut

Project Number

Project Number

5R01MH089176-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Biological correlates of altered brain growth in autism | 1011793 | 2009 | 1R01MH089176-01

 
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