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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The genetics of restricted, repetitive behavior: An inbred mouse model

Principal Investigator

Principal Investigator

Lewis, Mark

Description

Description

In this study, Dr. Lewis and colleagues will develop a mouse model of restricted, repetitive behaviors (RRBs) which will allow them to identify variations in the mouse genome associated with these behaviors. These researchers have previously identified an inbred mouse line that displays both repetitive behaviors (jumping, flipping, and weaving) and restricted behaviors (reduced exploration of the environment). The present research will examine the genetic basis of these behaviors, characterizing the regions of genomic DNA which are associated with these behaviors. This may lead to the identification of gene variants which are involved in the development of RRBs. The examination of genetic variation in a mouse model of RRB should have direct value for clinical genetic studies of ASDs, and aid in understanding the underlying biology of this diagnostic feature of autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

60000

Current Award Period

Current Award Period

2008-2010

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

The genetics of restricted, repetitive behavior: An inbred mouse model (External web link)

Institution

Institution

University of Florida

State/Country

State/Country

Florida

Project Number

Project Number

2533

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The genetics of restricted, repetitive behavior: An inbred mouse model | 60000 | 2009 | 2533
The genetics of restricted, repetitive behavior: An inbred mouse model | 60000 | 2008 | 2533

 
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