Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Studies of central nervous system functional anatomy

Principal Investigator

Principal Investigator

Herkenham, Miles

Description

Description

In clinical studies, correlations have been reported between maternal infections and higher prevalence of mental illness in their children. These researchers use the maternal immune activation (MIA) model to study disorders with early neurodevelopmental etiology, such as schizophrenia, autism, and anxiety disorder. In a set of experiments performed in rats, they have developed a MIA model in which pregnant dams are subjected to an immune challenge (LPS administration) at day 15 of gestation, and the offspring are studied for behavioral alterations (like social deficits that mirror autism and cognitive dysfunctions that mirror schizophrenia) and their underlying biochemical causes.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

1048141

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2.2 Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years.

Project Link

Project Link

No link available.

Institution

Institution

National Institutes of Health

State/Country

State/Country

Maryland

Project Number

Project Number

Z01MH001090-31

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Studies of central nervous system functional anatomy | 1340580 | 2009 | 1ZIAMH001090-32

 
Back to Top