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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Investigation of IL-9, IL-33 and TSLP in serum of autistic children

Principal Investigator

Principal Investigator

Theoharides, Theoharis

Description

Description

Levels of pro-inflammatory cytokines (IL-6, TNF) in the serum of autistic children have been inconclusive. However, recent findings indicate that chemokines (eotaxin, MCP-1, RANTES) are elevated in this population. These chemokines are responsible for accumulation of mast cells and mast cell activation, and they have been shown to be associated with autism. In this research project, levels of IL-9, IL-33, and TSLP, new cytokines recently considered “alarmins” through mast cell activation, will be measured in the serum of autistic children along with age and sex-matched neurotypical controls. Interactions among these key molecules may prove useful for both potential biomarkers and novel targets for treatment.

Funder

Funder

Autism Research Institute

Fiscal Year Funding

Fiscal Year Funding

8650

Current Award Period

Current Award Period

2011.0

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Investigation of IL-9, IL-33 and TSLP in serum of autistic children (External web link)

Institution

Institution

Tufts University School of Medicine

State/Country

State/Country

Massachusetts

Project Number

Project Number

2011-11

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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