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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Primate models of autism

Principal Investigator

Principal Investigator

Bauman, Melissa

Description

Description

Evidence suggests that maternal autoantibodies directed against fetal brain tissue are a possible cause for a subset of autism cases. A characteristic pattern of autoantibody production to human fetal brain tissue (and to rhesus monkey brain tissue) in 20% of mothers of multiple children with autism was recently identified. These studies indicate that rhesus monkeys, prenatally exposed to IgG class antibodies from these mothers, produce whole body motor stereotypies indicative of autism symptoms. Research on this immunological model of autism will be extended in this study by increasing the number of experimental subjects and increasing the duration of IgG exposure into the second trimester for a subset of the subjects. Behavioral observations of the first two years of development will be made in both treated and untreated animals to compare behavior in a variety of social contexts designed to probe attachments, social dominance, social motivations, and fear reactions. A detailed longitudinal magnetic resonance imaging (MRI) study of the brain regions most commonly implicated in the neuropathology of autism will also be carried out in order to evaluate differences in the time course of brain development. Collectively, these studies may have direct implications for diagnosis, prevention, and treatment of ASD.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

75629

Current Award Period

Current Award Period

2011-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Primate models of autism (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

5P51RR000169-50

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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