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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Genome-wide expression profiling data analysis to study autism genetic models

Principal Investigator

Principal Investigator

Luo, Rui

Description

Description

Previous studies indicate that autism spectrum disorders (ASDs) can be conceptualized as the result of multiple rare and common variants that act in combination to shape different aspects of cognition and behavior. It has been proposed that autism spectrum disorders are caused by combinations of multiple genetic variants, or mutations that affect many essential genes to shape different aspects of cognition and behavior. This study aims to test that model in an attempt to explain possible risk factors of autism. Using gene expression data from more than 1000 blood samples from patients with autism and their unaffected family members, gene signatures will be examined in order to classify disease subgroups. This is the first time such a large data set has been used for a comprehensive gene expression study in ASD. The project has the potential to advance the understanding of autism and contribute to disease diagnosis and treatment. The study will first focus on whether there are consistent gene expression changes between cases and controls, which can help us find biomarkers for ASDs diagnosis. It will then focus on the expression pattern for each individual to see whether there are genes that behave significantly differently in certain cases, which will likely promote the realization of personalized medicine.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

28000

Current Award Period

Current Award Period

2011-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Project Link

Project Link

Genome-wide expression profiling data analysis to study autism genetic models (External web link)

Institution

Institution

University of California, Los Angeles

State/Country

State/Country

California

Project Number

Project Number

7436

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Genome-wide expression profiling data analysis to study autism genetic models | 0 | 2012 | 7436
Genome-wide expression profiling data analysis to study autism genetic models | 0 | 2013 | 7436

 
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