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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

CNS toxicity of ambient air pollution: Postnatal exposure to ultrafine particles

Principal Investigator

Principal Investigator

Cory-Slechta, Deborah

Description

Description

Increasing evidence suggests that ultrafine particle (UFP) air pollution may produce sustained brain inflammation. UFP might be predicted to produce brain effects similar to those seen with maternal/neonatal inflammation, components of which are considered models of schizophrenia, autism, cerebral palsy, mental retardation, and Parkinson's disease. Consistent with this possibility, preliminary data shows that postnatal UFP exposures results in sustained brain inflammation in mice as adults in ventral midbrain and hippocampus, brain regions key to mediating complex cognition and motor functions. Such residual inflammation suggests that developmental UFP exposure may represent a heretofore largely underappreciated risk factor for neurodevelopment dysfunction in children or a fetal risk factor for neurodegenerative diseases. In this study, researchers will test whether developmental UFP exposures of mice can affect cognitive and/or locomotor behavior. They will also explore cellular and molecular changes, including alterations in levels of brain cytokines, inflammation, oxidative stress, neurotransmitters and/or plasma corticosterone. Positive findings would suggest that UFP represents a previously underappreciated basis for brain dysfunction and could lead to significant advances in understanding the contribution of air pollutants to the etiology of neurodevelopment and neurodegenerative disorders, including autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

229433

Current Award Period

Current Award Period

2010-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

CNS toxicity of ambient air pollution: Postnatal exposure to ultrafine particles (External web link)

Institution

Institution

University of Rochester

State/Country

State/Country

New York

Project Number

Project Number

5R21ES019105-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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