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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Neuroligin function in vivo: Implications for autism and mental retardation

Principal Investigator

Principal Investigator

Powell, Craig

Description

Description

Autism spectrum disorder and mental retardation are common, debilitating disorders involving social interaction or cognitive function with clinical overlap in a subset of patients. Recently, loss-of-function mutations in members of the Neuroligin family of trans-synaptic cell adhesion molecules have been implicated in human autism and mental retardation. Mice with genetic alterations of Neuroligin will be electrophysiologically and behaviorally characterized as potential animal models of autism and mental retardation in an effort to better understand the cause and treatment of these debilitating disorders.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

388575

Current Award Period

Current Award Period

2008-2013

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Neuroligin function in vivo: Implications for autism and mental retardation (External web link)

Institution

Institution

University of Texas Southwestern Medical Center

State/Country

State/Country

Texas

Project Number

Project Number

5R01MH081164-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Neuroligin function in vivo: Implications for autism and mental retardation | 388575 | 2012 | 5R01MH081164-04

 
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